Pramiracetam is a very well-known nootropic that was developed in the late 1970s. It has been researched almost continuously since its development in 1978. Pramiracetam is one of the strongest nootropics available. It increases mental performance and even intelligence. It doesn’t make you smarter from one second to the next, but it improves memory, ability to learn, judgment, and even focus and mental energy. Before taking Pramiracetam for the first time, you should carefully read about the drug to know how it optimizes cognitive processes by increasing activity at the neuroreceptors. The following explains in more detail how pramiracetam works, what advantages it has, what dosage works well and what kind of side effects can occur.


As with most nootropics, the exact mechanisms of action of pramiracetam have not yet been fully understood. However, it is certain that the agent gets into the bloodstream through fatty acids in the intestine. After it has reached the maximum concentration in the blood, which usually happens after about an hour, it is immediately transported to the brain by unhindered passage through the blood-brain barrier, where it works very effectively. There it enhances the effect of acetylcholine, one of the most important neurotransmitters in the human brain, on the respective receptors.

This neurotransmitter is responsible for a large number of cognitive functions. These functions include memory and learning ability, but also the creation of new nerve cells and connections between them. The main mode of action of Pramiracetam is that it supports the absorption of acetylcholine in the hippocampus, the part of the brain that is responsible for storing and ordering new memories. By manipulating the receptors for this neurotransmitter, it can increase the amount of acetylcholine in the brain and make communication between nerve cells faster and easier.


One of the main advantages of Pramiracetam is that, like many other racetams, it boosts blood circulation in the brain. This increased circulation allows much more oxygen to enter the blood. The glucose metabolism is also promoted. This can lead to the brain having more energy: the mental readiness is increased and one is clearer in the head. This goes hand in hand with an increased attention span, better concentration, and focus, faster thinking and more effective processing of information.

Pramiracetam can also have great advantages when it comes to brain memory and learning capacity. As with many nootropics, these effects can vary greatly from person to person. Some users may find it extremely minor, while others feel very strong improvements in the areas mentioned – and that after a short time. Activities such as reading, writing, and talking are also easier to do. Reminders can be called up more quickly. The remedy is also very helpful for a number of serious mental illnesses: significant improvements could be measured in cases of Alzheimer’s, ADHD, dementia and other illnesses.


Since the agent is very strong, you should not and should not be consumed in high doses. Pramiracetam has been shown to be up to 30 times stronger than the well-known piracetam from which it was derived. A dose of 500 mg two or three times a day can work wonders. A division into at least two daily doses should be made, preferably one in the morning and one in the afternoon, in order to balance the half-life of 5 hours that Pramiracetam has in the body. This allows a constant level of pramiracetam to be maintained in the bloodstream. This dosage can, of course, be combined according to personal preferences for advanced users.

Different people can tolerate the remedy differently well and it also works differently effectively. In addition, a certain tolerance towards the agent can develop over time. In general, however, Pramiracetam should not be taken in too high doses, because the benefits may wane and unwanted results could occur. This product is also not suitable for an “attack dose” or any other short-term overdose, the recommended maximum dose of 1.5 grams per day should not be exceeded too much.

Potential Side Effects

Pramiracetam can be tolerated very well by healthy adults – no serious side effects have ever been reported. It does not interact maliciously with other means and is completely non-toxic. However, a doctor should always be consulted before starting Pramiracetam or similar agents. In general, however, the remedy is very safe and side effects are rare and if they do occur, only very slightly. The most common side effects, like many racetams, are headaches due to the low choline level caused by the drug. In combination with Alpha GPC or Citicoline, however, this side effect is also eliminated.

Pramiracetam Conclusion

If you take this into account and the dosage guidelines, Pramiracetam can be used without hesitation to increase cognitive performance so that everyday life, work or school can be achieved not only with more mental energy but also with real performance gains.