Piracetam

Piracetam is a nootropic drug that is used by millions of users worldwide. Piracetam is said to have a number of positive effects such as improving skills like learning and remembering. It also increases attention, concentration, mood, and motivation. It works by affecting certain processes between neurons in the brain and accelerating the transfer of information between them.

According to scientists, this racetam has a protective and optimizing effect on the cerebral cortex, which also improves communication skills. This part of the brain is also responsible for thoughts, reasoning, perception, and movement.

History

Piracetam was the first remedy within the Racetam family. It was first synthesized in 1964 in Belgium in the laboratory of UCB Pharma to improve communication between brain cells and the two hemispheres of the brain. It is chemically very similar to pyroglutamic acid. It differs from it only by a single molecular chain. Piracetam has been produced under many different trade names over time. Some of them are Cerebrospan, Encefalux, Nootron, Nootropil, Psycotron, and Stimucortex.

The development of Piracetam made it necessary to define a completely new category of supplements – the nootropics were born. The word “nootropic”, which comes from the Greek and roughly translated means “to bend/shape the mind”, was developed to name Piracetam.

Today, Piracetam is mainly used to prevent the decline in cognitive performance and to improve this performance in healthy people.

Effect

While the totality of all the effects of Piracetam is not yet known, it is believed to increase the permeability of cell membranes. Thus it increases the supply and distribution of oxygen molecules in the brain. It also increases the flow of blood into neuronal tissue, which has another protective effect on neuronal structures such as neurons and synapses. Better blood circulation keeps the tissue healthy and protects against age-related damage and regression. It also plays a role in the removal of toxins and waste products from the cells by increasing the speed at which the cells expel these substances. The health of cell membranes is also important to prevent oxygen deficiency and thus prevent diseases caused by a lack of oxygen in the brain.

Piracetam also influences the glucose level in the brain. More specifically, it prevents the reabsorption of glucose. This stimulates the production of glucose, which leads to higher reactivity and energy.

It has been proven that Piracetam also has an effect on the amount of calcium in the brain, which strengthens the connection between nerve cells. This nootropic is similar to GABA, also known as aminobutyric acid, a known neurotransmitter, but differs in that it does not activate the GABA receptors.

It has been shown that the drug also increases the amount of cAMP in the brain, a so-called “second messenger” that is involved in the transmission of signals between brain cells. It improves the function of the mitochondria, i.e. the cell power stations, particularly in aged brains.

According to a 1993 report published in the journal Pharmacology, Piracetam can increase the interactivity between L-glutamate and NMDA receptors. NMDA is particularly important for memory formation and stimulates the growth of neuronal connections. This could be a key factor in the reduction of aging processes by Piracetam.

Usage

Piracetam supports a wide range of brain functions. The reasons why people consume Piracetam are very diverse. Perhaps the best-known benefits of the drug are improvements in the aspects of learning and memory. From 1976 onwards, studies have shown more and more often that Piracetam could induce considerable improvements in working memory above a dosage of 1200 mg. Another study in 1991 in New Zealand showed that Piracetam promotes memory and the learning of new skills and facts through changes in the corpus callosum. The same study also showed that the drug promotes cholinergic activities that have a positive effect on learning ability.

Piracetam is very well able to cross the blood-brain barrier and interact with the glutamate receptors in the brain. These and other neuroreceptors are jointly responsible for recognition and memory in parts of the brain. However, the respective effects may differ from person to person. Some users describe only small improvements in their memory and thought processes, while others are able to recall whole dreams or even the smallest details of certain events. Concentration and attention are also improved by Piracetam because it supports blood circulation in the brain. Users may also notice an increased ability to think and a better attention span after taking this nootropic. It is also often emphasized that everyday tasks such as reading and writing are faster and more fluent than before taking the drug.

As it increases the activity of the receptors in the brain, improvements in perception and sensory perception also occur. Many users report an increased ability to distinguish small details when seeing, smelling and hearing. The memory of visual, auditory and olfactory stimuli, i.e. the perceptions of the senses of sight, hearing, and smell, is also better stored. In addition, the brain can better link these with other memories. These effects are particularly often more pronounced at the beginning of taking Piracetam: many users tell of brighter colors and a better sense of hearing.

Piracetam also has a very positive influence on the user’s motivation and mood. In many cases, users report more energy in everyday life, both physically and mentally. Several studies have also found effects of Piracetam that help people who have been predicted to suffer from depression. In this area, the drug is particularly promising. Research shows that damage to certain areas of the brain, especially in old age, can cause symptoms of depression. When Piracetam is administered to older people, the increased blood circulation in the brain can not only reduce the depression but can also brighten the mood in general. Furthermore, it has often been reported that Piracetam can also be helpful for symptoms of anxiety or sleep disorder. Research in this area is not yet as advanced and it is not clear what mechanisms cause these effects.

Not only the oxygen supply to the brain can be improved by Piracetam, but also the processing of this important substance can be significantly increased. In practice, this can reduce fatigue, increase attention span and alertness and achieve an effect that protects the neurons in the long term. Many complaints associated with insufficient blood circulation in the brain can be alleviated by Piracetam. It can also help suffocation victims by improving blood flow to the brain.

Some studies show that Piracetam can also help with reading disorders. In the study of 600 children who had such a disorder, Piracetam was able to improve both the children’s verbal expression and their reading comprehension.

In old age, the drug can work wonders. It can not only prevent age-related degeneration processes but also have a positive effect on the patient’s memory, expressiveness, and concentration. Widespread symptoms of old age such as poor short-term memory and cognitive degeneration can be eradicated, thus making life in old age more bearable again.

Side Effects

In the standard dosage, Piracetam is completely harmless to the human body. Since it is water-soluble, the body can simply excrete excess amounts of the drug with the urine. This makes it very safe, as it is very difficult to overdose. An overdose of Piracetam has not caused any physical or mental harm in any known case. Even in cases where users have taken doses exceeding 5 grams per day, no toxic effects of the drug have been detected. Studies have shown that it is less toxic than table salt or caffeine.

Users report that Piracetam is very well accepted by the body. Very few side effects are known – only 10 percent of users have had any negative experience with taking this nootropic. Sometimes, for example, mild headaches can occur, but this can easily be compensated by taking a choline supplement. Other side effects may include mild anxiety, nervousness, agitation, but also slight dizziness.

These side effects are extremely rare and occur only very briefly, if at all.

Long term studies show that Piracetam provides excellent results. In 1993, scientists found that 8 grams a day produced a significant improvement in memory in Alzheimer’s patients. The progression of the disease was greatly slowed down and no side effects were observed. Healthy users usually take a much smaller dose per day. Therefore side effects are hardly to be expected.

In some cases, however, the body may develop a tolerance to Piracetam. In other cases, users may not notice any effect in the first few weeks of use. In some people, it may take some time for the drug to reach a dose in the body that can effectively improve cognitive performance.

In other cases, a short high dose of the drug, two or three times the usual dosage for a few days, may help to bring the concentration of Piracetam in the body to a certain level.

Piracetam in combination with other substances

There are a few substances that are not recommended to be taken together with Piracetam. In most cases, this is due to the fact that Piracetam strongly promotes blood circulation in the brain. It is always better to be on the safe side if nootropics are to be taken together with medicines and other remedies. So talk to your doctor before you take this or any other nootropics to make sure that your medical history or other substances you have taken do not make it dangerous.

As Piracetam improves blood flow in the brain, as mentioned above, alcohol consumption, for example, can have strong negative effects. Even smaller amounts than you are used to can lead to severe alcohol poisoning, as the brain is much better supplied with blood and therefore the alcohol has a stronger effect in larger quantities. Amphetamines are also not recommended. Piracetam can multiply the effect of these drugs, which can lead to high blood pressure and ventricular fibrillation. This is often accompanied by concentration difficulties and anxiety. Another group of substances that should not be taken in combination with Piracetam are blood thinners. Taking both substances can lead to heavy bleeding in the case of a wound and to tissue damage.

Piracetam can be safely taken with other nutrients, vitamins and nootropic performance enhancers. We have listed a few of these combinations as stacks for you below.

Dosage Guidelines

Piracetam can work effectively in many different dosages. A low dose of 400 mg is the minimum, while most people take 800 mg of Piracetam per intake. However, some people need to take a higher dose at the beginning for the Piracetam to be fully effective. This can happen in two ways.

First of all, you can start with a dose called an attack dose. This is very popular to start taking different nootropics. In this case, an increased dose of two to three times the usual dose is administered over the first few days. However, this practice should only be used with water-soluble, easily tolerated drugs such as Piracetam. The dose should never be so high that it could harm the body.

The other way to start taking Piracetam is to take it over a period of three weeks, gradually reducing the dose, starting at high doses. After this period of time, it will be used normally again.

Many studies have been conducted to find the best dose that will give optimal results with Piracetam. In general, it is recommended to take higher doses once tolerance for the drug has been established. Since Piracetam is very well tolerated, higher doses are also relatively safe.

According to users, a dose of 4 grams is the most effective. The effects are most likely to be felt 1 to 4 hours after ingestion, so you should plan your daily routine accordingly by carrying out tasks requiring high cognitive performance during this time if possible. Piracetam can be purchased as a powder or in the form of pills, but Piracetam powder is quite bitter when taken without additives. However, it can be dissolved in orange juice, for example, and taken throughout the day, or it can be drunk immediately.

Stacking

To reinforce a nootropic, it can be stacked. In doing so, several different remedies are combined to achieve a greater overall effect than when only one of the substances contained is taken. Thanks to its low toxicity and low side effects, Piracetam can easily be taken in combination with various other nootropics. For example, it can be taken in combination with choline. This combination is probably the most common. The effects that choline has on memory, logical thinking and concentration are well known. As Piracetam uses up the body’s reserves of choline, which as mentioned above can lead to headaches in some cases due to deficiency, adding choline can compensate for this effect and thus enhance the overall effect of Piracetam. If Piracetam is combined with other racetams such as aniracetam and oxiracetam, they have a very positive effect on memory. In combination with caffeine, vinpocetine, and choline, it can additionally strengthen the blood flow in the brain through the combination of Piracetam and vinpocetine and at the same time increase energy through the caffeine and neuroplasticity through the choline.

Piracetam Experiences

Most users report positively about Piracetam. It is widely known as a tolerable, easily consumed nootropic drug with few side effects, which effectively increases the performance of the brain. Many users have clearer and more accessible memories and better memory, for which Piracetam is most recognized. They can remember images, situations, names, and experiences in greater detail and more quickly. Even long lost childhood memories sometimes reappear with Piracetam. Users of Piracetam also report that the remedy defogs the head and makes for much clearer thought processes. It can dissolve mental blocks at school and at work and prevents lethargic states, making you more productive and communicative. There are also reports of more vivid and detailed dreams when the remedy is taken in the evening hours. Some users compare these dreams to very exciting movies. However, some users have the problem that they get tired as soon as the dose of Piracetam decreases. This effect can also be counteracted with choline.

Is it legal?

Piracetam is still not approved as a drug in the USA because it has not yet been tested by the authorities. In other countries, Piracetam has been used for decades and is also prescribed by doctors. In these countries, it is legal to buy, sell and consume the substance. Alternatively, you can also use phenylpiracetam, which is available without a prescription.